Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson''s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson''s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.- Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors- Preclinical models in COMT inhibitor devlopment- Transgenic COMT mice – latest information summarized- Chemistry of COMT inhibitors and their design with molecular modelling- COMT gene and its regulation and relation to dopamine related diseases- Role of cofactor SAM regulation in relation to homocysteine- Nonclinical and clinical safety of COMT inhibitors summarized- Future prospects of COMT inhibitors in Parkinson''s disease